Zhu Yi was the son of Zhu Huan and succeeded him when Zhu Huan died. His courtesy name was Jiwen. Through his father's privilege he was appointed a gentleman (lang), later became Chief Commandant of Cavalry and commanded troops in place of Zhu Huan. In the 4th year of Chiwu (241), when he followed Zhu Ran in attacking Wei's Fancheng, he devised a plan that broke its outer defenses, and on his return he became Lieutenant General (pian jiangjun). The Biography of Lü Ju also records that at this time Lü Ju, together with Zhu Yi, broke the defenses outside the city. Records, Wu 11 §61 · 63 · 43
Wen Qin, Wei's Administrator of Lujiang, kept his camp at Lu'an and set up many camps and stockades at the strategic points of the various roads, luring fugitives and deserters and raiding the border. Zhu Yi personally led 2,000 of his own men in a surprise attack that broke seven of Wen Qin's camps and took several hundred heads, and he was promoted to General Who Displays Martial Might. When Sun Quan discussed attacks and battles with him, his answers pleased him. Sun Quan said to Zhu Ju, General of Agile Cavalry and Zhu Yi's uncle, 'I always knew Jiwen's courage was firm, but seeing him for myself, he surpasses what I had heard.' Records, Wu 11 §63–64
In the 10th month, in winter, of the 13th year of Chiwu (250), Wen Qin feigned surrender and secretly sent Zhu Yi a letter, hoping to make him come in person to receive him. Zhu Yi submitted a memorial presenting Wen Qin's letter and stated that it was a deception and that Wen Qin should not be received at once. Sun Quan issued an edict saying that since the northern lands were not yet united, Wen Qin should be received for now, and that if a trick was suspected, they had only to spread a net of stratagems and station heavy forces to guard against it. He therefore had Lü Ju lead 20,000 men to join forces with Zhu Yi, but when they reached the northern frontier, Wen Qin did indeed not surrender. Records, Wu 11 §64–65Records, Wu 2 §108
In the 1st year of Jianxing (252) he was promoted to General Who Guards the South. That year, when Wei sent Hu Zun, Zhuge Dan and others out to Dongxing, Zhu Yi led the navy to attack the pontoon bridge and destroyed it, and the Wei army was heavily defeated. Later, when Zhuge Ke advanced into Huainan, failed to take the city and showed his frustration, the general Zhu Yi argued the rights and wrongs with him, and Zhuge Ke in his anger immediately took away his troops. Records, Wu 11 §65Records, Wu 19 §44–45
The Biographies of the Three Successor Rulers record that in the 3rd month of the 2nd year of Wufeng (255) the General Who Guards the South Zhu Yi was sent to make a surprise attack on Anfeng but did not succeed. In the 8th month of the 1st year of Taiping (256), Sun Jun, adopting Wen Qin's plan to attack Wei, first sent Wen Qin, Lü Ju, Liu Zuan, Zhu Yi and Tang Zi to enter the Huai and Si rivers from Jiangdu, but when Sun Jun died in the 9th month, his successor Sun Chen recalled Lü Ju and the others. Records, Wu 3 §9–10 · 12Records, Wu 19 §76
In the 5th month of the 2nd year of Taiping (257), when Wei's General-in-Chief Who Conquers the East Zhuge Dan declared himself a subject of Wu at Shouchun, Wu in the 6th month gave Wen Qin, Tang Zi, Quan Duan and others 30,000 men to relieve him. Meanwhile Sun Chen sent Zhu Yi to make a secret attack on Sun Yi, the Commander at Xiakou, and when Zhu Yi arrived Sun Yi fled to Wei. In the 7th month, when Sun Chen halted at Huoli, he made Zhu Yi, who had come from Xiakou, Commander of the Front Division and had him, together with Ding Feng and others, lift the siege with 50,000 armored soldiers. The Biography of Zhu Yi records that at this time he was granted the tally of authority and made Grand Commander. Records, Wu 3 §15–16Records, Wu 6 §22Records, Wu 11 §65
Zhu Yi led 30,000 men to garrison Anfeng as support for Wen Qin, but when Wei's Inspector of Yan Province Zhou Tai (州泰) blocked him at Yangyuan, he was defeated and withdrew, and under pursuit he lost 2,000 killed or wounded. Leading 50,000 men again with Ding Feng, Li Fei and others, he left his baggage train at Dulu and encamped at Lijiang, and had the generals Ren Du, Zhang Zhen and others recruit 6,000 brave men to build a pontoon bridge six li to the west, cross by night and build a crescent-shaped rampart, but they were defeated by Wei's Army Supervisor Shi Bao and Zhou Tai. He formed a camp of wagons ringed like a box and advanced on Wumu, but was defeated again and turned back, and Wei's Administrator of Taishan Hu Lie, with a surprise force of 5,000, raided Dulu and burned all of Zhu Yi's supplies and provisions. Records, Wu 19 §84–86
Sun Chen gave Zhu Yi 30,000 troops and ordered him to fight to the death, and when Zhu Yi would not obey, he beheaded him at Huoli. The Biographies of the Three Successor Rulers record that when Zhu Yi brought his army back saying the soldiers had run out of food, Sun Chen flew into a rage and killed him at Huoli on the day jisi, the first day of the 9th month, while the Biography of Zhuge Dan in the Records of Wei records that Sun Chen killed him in anger because Zhu Yi fought but could not advance. The Biography of Zhu Yi writes that he turned his army back and was wrongfully put to death by Sun Chen. Since Sun Chen had failed to rescue Zhuge Dan, lost his soldiers and killed a famous general himself, there was no one who did not resent him. Records, Wu 19 §86Records, Wu 3 §17Records, Wei 28 §38Records, Wu 11 §65
In his assessment, Chen Shou said that Lü Ju, Zhu Yi and Shi Ji all had the talent of commanders and ably carried on their fathers' work. He wrote that Lü Fan and Zhu Huan had faults yet ended their lives well, whereas Lü Ju and Zhu Yi, without such faults, met with disaster instead, because the times they met with were different. Records, Wu 11 §67